The Merging of a Coronal Dimming and the Southern Polar Coronal Hole

We report on the merging between the southern polar coronal hole and an adjacent coronal dimming induced by a coronal mass ejection on 2022 March 18, resulting in the merged region persisting for at least 72 hr. We use remote sensing data from multiple co-observing spacecraft to understand the physical processes during this merging event. The evolution of the merger is examined using Extreme-UltraViolet (EUV) images obtained from the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory and Extreme Ultraviolet Imager, which is on board the Solar Orbiter spacecraft. The plasma dynamics are quantified using spectroscopic data obtained from the EUV Imaging Spectrometer on board Hinode. The photospheric magnetograms from the Helioseismic and Magnetic Imager are used to derive the magnetic field properties. To our knowledge, this work is the first spectroscopical analysis of the merging of two open-field structures. We find that the coronal hole and the coronal dimming become indistinguishable after the merging. The upflow speeds inside the coronal dimming become more similar to that of a coronal hole, with a mixture of plasma upflows and downflows observable after the merging. The brightening of the bright points and the appearance of coronal jets inside the merged region further imply ongoing reconnection processes. We propose that component reconnection between the coronal hole and coronal dimming fields plays an important role during this merging event because the footpoint switching resulting from the reconnection allows the coronal dimming to intrude onto the boundary of the southern polar coronal hole

The SAMI Galaxy Survey: Shocks and Outflows in a normal star-forming galaxy

We demonstrate the feasibility and potential of using large integral field spectroscopic surveys to investigate the prevalence of galactic-scale outflows in the local Universe. Using integral field data from SAMI and the Wide Field Spectrograph, we study the nature of an isolated disk galaxy, SDSS J090005.05+000446.7 (z = 0.05386). In the integral field datasets, the galaxy presents skewed line profiles changing with position in the galaxy. The skewed line profiles are caused by different kinematic components overlapping in the line-of-sight direction. We perform spectral decomposition to separate the line profiles in each spatial pixel as combinations of (1) a narrow kinematic component consistent with HII regions, (2) a broad kinematic component consistent with shock excitation, and (3) an intermediate component consistent with shock excitation and photoionisation mixing. The three kinematic components have distinctly different velocity fields, velocity dispersions, line ratios, and electron densities. We model the line ratios, velocity dispersions, and electron densities with our MAPPINGS IV shock and photoionisation models, and we reach remarkable agreement between the data and the models. The models demonstrate that the different emission line properties are caused by major galactic outflows that introduce shock excitation in addition to photoionisation by star-forming activities. Interstellar shocks embedded in the outflows shock-excite and compress the gas, causing the elevated line ratios, velocity dispersions, and electron densities observed in the broad kinematic component. We argue from energy considerations that, with the lack of a powerful active galactic nucleus, the outflows are likely to be driven by starburst activities. Our results set a benchmark of the type of analysis that can be achieved by the SAMI Galaxy Survey on large numbers of galaxies.Comment: 17 pages, 15 figures. Accepted to MNRAS. References update

AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts

Abstract Deregulation of the cell cycle has long been recognized as an essential driver of tumorigenesis, and agents that selectively target key cell cycle components continue to hold promise as potential therapeutics. We have developed AZD5438, a 4-(1-isopropyl-2-methylimidazol-5-yl)-2-(4-methylsulphonylanilino) pyrimidine, as a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2, and 9 (IC 50 , 16, 6, and 20 nmol/L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC 50 range, 0.2-1.7 μmol/L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH-terminal domain and blocking cell cycling at G 2 -M, S, and G 1 phases. In vivo, when orally administered at either 50 mg/kg twice daily or 75 mg/kg once daily, AZD5438 inhibited human tumor xenograft growth (maximum percentage tumor growth inhibition, range, 38-153; P < 0.05). In vivo, AZD5438 reduced the proportion of actively cycling cells. Further pharmacodynamic analysis of AZD5438-treated SW620 xenografts showed that efficacious doses of AZD5438 (>40% tumor growth inhibition) maintained suppression of biomarkers, such as phospho-pRbSer 249 /Thr 252 , for up to 16 hours following a single oral dose. A comparison of different schedules indicated that chronic daily oral dosing provided optimal cover to ensure antitumor efficacy. These data indicate that broad cdk inhibition may provide an effective method to impair the dysregulated cell cycle that drives tumorigenesis and AZD5438 has the pharmacologic profile that provides an ideal probe to test this premise

Moving forward in microplastic research: A Norwegian perspective

Given the increasing attention on the occurrence of microplastics in the environment, and the potential envi-ronmental threats they pose, there is a need for researchers to move quickly from basic understanding to applied science that supports decision makers in finding feasible mitigation measures and solutions. At the same time, they must provide sufficient, accurate and clear information to the media, public and other relevant groups (e.g., NGOs). Key requirements include systematic and coordinated research efforts to enable evidence-based decision making and to develop efficient policy measures on all scales (national, regional and global). To achieve this, collaboration between key actors is essential and should include researchers from multiple disciplines, policy-makers, authorities, civil and industry organizations, and the public. This further requires clear and informative communication processes, and open and continuous dialogues between all actors. Cross-discipline dialogues between researchers should focus on scientific quality and harmonization, defining and accurately communi-cating the state of knowledge, and prioritization of topics that are critical for both research and policy, with the common goal to establish and update action plans for holistic benefit. In Norway, cross-sectoral collaboration has been fundamental in supporting the national strategy to address plastic pollution. Researchers, stakeholders and the environmental authorities have come together to exchange knowledge, identify knowledge gaps, and set targeted and feasible measures to tackle one of the most challenging aspects of plastic pollution: microplastic. In this article, we present a Norwegian perspective on the state of knowledge on microplastic research efforts. Norway’s involvement in international efforts to combat plastic pollution aims at serving as an example of how key actors can collaborate synergistically to share knowledge, address shortcomings, and outline ways forward to address environmental challenges.publishedVersio

Condom and Oral Contraceptive Use and Risk of Cervical Intraepithelial Neoplasia in Australian Women

Objective: To assess the association between condom use and oral contraceptive consumption and the risk of cervical intraepithelial neoplasia (CIN).Methods: A cross-sectional study was conducted in Perth clinics. A total of 348 women responded to the structured questionnaire. Information sought included demographic and lifestyle characteristics such as the use of condom for contraception, consumption of oral contraceptive, and duration of oral contraceptive usage. Crude and adjusted odds ratio (OR) and associated 95% confidence interval (CI) were calculated using unconditional logistic regression models and reported as estimates of the relative risk. Results: The prevalence of CIN was found to be 15.8%. The duration of oral contraceptive consumption among women with abnormal Papanicolaou (Pap) smear result indicating CIN was significantly shorter than those without abnormal Pap smear result (mean±SD, 5.6±5.2 years vs. 8.2±7.6 years; p=0.002). Comparing to =3 years usage, prolonged consumption of oral contraceptive for =10 years reduced the risk of CIN (p=0.012). However, use of condom for contraception might not be associated with a reduced risk of CIN after accounting for the effects of confounding factors (adjusted OR, 0.52; 95% CI, 0.05 to 5.11; p=0.577).Conclusion: Use of oral contraceptives, but not condoms, for contraception appeared to be inversely associated with CIN. Prolonged use of oral contraceptive demonstrated its benefits of reducing the risk of CIN

Reproductive factors for ovarian cancer in southern Chinese women

Objective: To investigate the association between reproductive factors and the risk of ovarian cancer among southern Chinese women. Methods: A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, between 2006 and 2008. A structured questionnaire was used to obtain information on parity, oral contraceptive use and other reproductive factors in a sample of 500 incident ovarian cancer patients and 500 controls (mean age, 59 years). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models. Results: High parity was inversely associated with ovarian cancer, with an adjusted OR 0.43 (95% CI, 0.30 to 0.62) for women who had given birth to 3 or more children compared to women who had given no more than one birth. Ever use of oral contraceptives was also protective against ovarian cancer; adjusted OR 0.56 (95% CI, 0.40 to 0.78). No association was found for hormone replacement therapy, menopausal status, hysterectomy and family history of ovarian and/or breast cancer. Conclusion: High parity and oral contraceptive use are associated with a lower risk of ovarian cancer in southern Chinese women

The SAMI Galaxy Survey: : extraplanar gas, galactic winds, and their association with star formation history

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. ©: 2016 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society, the version of record is available on line at doi: 10.1093/mnras/stw017We investigate a sample of 40 local, main-sequence, edge-on disc galaxies using integral field spectroscopy with the Sydney-AAO Multi-object Integral field spectrograph (SAMI) Galaxy Survey to understand the link between properties of the extraplanar gas and their host galaxies. The kinematics properties of the extraplanar gas, including velocity asymmetries and increased dispersion, are used to differentiate galaxies hosting large-scale galactic winds from those dominated by the extended diffuse ionized gas. We find rather that a spectrum of diffuse gas-dominated to wind dominated galaxies exist. The wind-dominated galaxies span a wide range of star formation rates ($-1 \lesssim \log({\rm SFR/M_{\odot} yr^{-1}}) \lesssim 0.5$) across the whole stellar mass range of the sample ($8.5 \lesssim \log({\rm M_{*}/M_{\odot}}) \lesssim 11$). The wind galaxies also span a wide range in SFR surface densities ($10^{-3} \textrm{--} 10^{-1.5}\rm~M_{\odot} ~yr^{-1}~kpc^{-2}$) that is much lower than the canonical threshold of $\rm0.1~M_{\odot} ~yr^{-1}~kpc^{-2}$. The wind galaxies on average have higher SFR surface densities and higher $\rm H\delta_A$ values than those without strong wind signatures. The enhanced $\rm H\delta_A$ indicates that bursts of star formation in the recent past are necessary for driving large-scale galactic winds. We demonstrate with Sloan Digital Sky Survey data that galaxies with high SFR surface density have experienced bursts of star formation in the recent past. Our results imply that the galactic winds revealed in our study are indeed driven by bursts of star formation, and thus probing star formation in the time domain is crucial for finding and understanding galactic winds.Peer reviewe

Disordered microbial communities in asthmatic airways.

A rich microbial environment in infancy protects against asthma [1], [2] and infections precipitate asthma exacerbations [3]. We compared the airway microbiota at three levels in adult patients with asthma, the related condition of COPD, and controls. We also studied bronchial lavage from asthmatic children and controls.We identified 5,054 16S rRNA bacterial sequences from 43 subjects, detecting >70% of species present. The bronchial tree was not sterile, and contained a mean of 2,000 bacterial genomes per cm(2) surface sampled. Pathogenic Proteobacteria, particularly Haemophilus spp., were much more frequent in bronchi of adult asthmatics or patients with COPD than controls. We found similar highly significant increases in Proteobacteria in asthmatic children. Conversely, Bacteroidetes, particularly Prevotella spp., were more frequent in controls than adult or child asthmatics or COPD patients.The results show the bronchial tree to contain a characteristic microbiota, and suggest that this microbiota is disturbed in asthmatic airways